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Although the use of exosomes as a delivery system has its drawback (for example, quickly eliminating by the reticuloendothelial system, lack of efficient encapsulation methods, and potential immune responses), exosomes targeted at tumors may allow systemic administration of miRNA as cancer treatment and are thus worthy of attention

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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.McCann J.C., Ames B.N

Clinical trials have utilized doses ranging from 1 mg per day up to 30 mg per day in divided doses for various administration routes, demonstrating safety across a wide dose spectrum

Am J Public Health 105:810815